CYDD_ECOLI/376-559 GQRAVLVGRSGSGKSSLLNALSGFLS.........YQGSLRING....IELRDLS......PESWRKHLSWVGQNPQLP...AATLRDN.VLLARPD..........................................................................................ASEQELQAAL...DNAWVSEFLPLLPQGV.......DTPVGDQAARLSVGQAQRVAVARALLNPC...SLLLLDEPAASLDAHSEQRVMEALNAASL...RQTTLMVTHQLED.LADW..DVIWVMQDG TAP1_HUMAN/531-718 GEVTALVGPNGSGKSTVAALLQNLYQ........PTGGQLLLDG....KPLPQYE....HRYLHRQ..VAAVGQEPQVF...GRSLQEN.IAYGLTQ.........................................................................................KPTMEEITAAA...VKSGAHSFISGLPQGY.......DTEVDEAGSQLSGGQRQAVALARALIRKP...CVLILDDATSALDANSQLQVEQLLYESPER.YSRSVLLITQHLSL.VEQA..DHILFLEGG APRD_PSEAE/359-543 GSVVGVIGPSGSGKSSLARVVLGIWP........TLHGSVRLDG....AEIRQYE......RETLGPRIGYLPQDIELF...AGTVAEN.IARFGEV...........................................................................................QADKVVEAA...RLAGVHELVLRLPQGY.......DTVLGVGGAGLSGGQRQRIALARALYGAP...TLVVLDEPNSNLDDSGEQALLAAIQALKAR..GCTVLLITHRAGV.LGCA..DRLLALNAG STE6_YEAST/1080-1263 GQTLGIIGESGTGKSTLVLLLTKLYN........CEVGKIKIDG....TDVNDWN......LTSLRKEISVVEQKPLLF...NGTIRDN.LTYGLQD.........................................................................................EILEIEMYDAL...KYVGIHDFVISSPQGL.......DTRIDT..TLLSGGQAQRLCIARALLRKS...KILILDECTSALDSVSSSIINEIVKKGPP...ALLTMVITHSEQM.MRSC..NSIAVLKDG MDR_PLAFF/406-638 GKTYAFVGESGCGKSTILKLIERLYD........PTEGDIIVNDS...HNLKDIN......LKWWRSKIGVVSQDPLLF...SNSIKNN.IKYSLYSLKDLEAMENYYEENTNDTYENK.............................................NFSLISNSMTSNELLEMKKEYQTIKDSDVVDVS...KKVLIHDFVSSLPDKY.......DTLVGSNASKLSGGQKQRISIARAIMRNP...KILILDEATSSLDNKSEYLVQKTINNLKGN.ENRITIIIAHRLST.IRYA..NTIFVLSNR ATM1_YEAST/462-648 GWKTAIVGSSGSGKSTILKLVFRFYD........PESGRILING....RDIKEYD......IDALRKVIGVVPQDTPLF...NDTIWEN.VKFGRID..........................................................................................ATDEEVITVV...EKAQLAPLIKKLPQGF.......DTIVGERGLMISGGEKQRLAIARVLLKNA...RIMFFDEATSALDTHTEQALLRTIRDNFTS.GSRTSVYIAHRLRT.IADA..DKIIVLDNG NIST_LACLA/379-568 GELTAIVGKNGSGKSTLVKIISGLYQ........PTMGIIQYDK....MRSSLMP......EEFYQKNISVLFQDFVKY...ELTIREN.IGLSDLS........................................................................................SQWEDEKIIKVL...DNLGLDFL..KTNNQYVL..DTQLGNWFQEGHQLSGGQWQKIALARTFFKKA...SIYILDEPSAALDPVAEKEIFDYFVALSE...NNISIFISHSLNA.ARKA..NKIVVMKDG YK83_YEAST/1312-1514 GTKVGIVGRTGAGKSSIIAAIYRLSD........WENGTITIDN....KDIKHIP......LERLRNSISCIPQDPTLF...DGTVRSN.LDPFDRYSDVQIYGVLSK...................................................................VGLIEECDELCLIFEQEQPNF........SSHKLRNRFIDL.......NTVVKSGGSNLSQGQRQLLCLARSMLGAR...NIMLIDEATASIDYISDAKIQKTIRETMK...NTTILTIAHRLRSVIDYD...KILVMEMG CFTR_BOVIN/1238-1420 GQRVGLLGRTGSGKSTLLLAFLRLLN.........TKGEIQIDG....VSWDSIT......LQQWRKAFGVIPQKVFIF...SGTFRKN.LDPYGQW...........................................................................................SDQEIWKVA...DEVGLRAVIEQFPGKL.......DFVLVDGGCVLSHGHKQLMCLARSVLSKA...KILLLDEPSAHLDPITYQIIRRTLKQAFAN...CTVILSEHRIEA.MLEC..QRFFVIEEN LCN3_LACLA/490-669 GEKIAIVGKSGSGKSTLFNILLGLIS.......YEGEVTYGYEN....LRQIIGVVS................QNMNLR...KGSLIEN.IVSNNNS........................................................................................EELDIQKINDVL...KDVNMLELVDSLPQKI.......FSQLFENGKNLSGGQIQRLLIAKSLLNNN...KFIFWDEPFSSLDNQNRIHIYKNVLENPDY.KSQTIIMISHHLDV.LKYV..DRVIYIDDK THIQ_ECOLI/25-206 GEQVAILGPSGAGKSTLLNLIAGFLT........PASGSLTIDG....VDHTTMP......PSRRP..VSMLFQENNLFS..HLTVAQN.IGLGLNP........................................................................................GLKLNAVQQGK........MHAIARQMGID.........NLMARLPGELSGGQRQRVALARCLVREQ...PILLLDEPFSALDPALRQEMLTLVSTSCQQ.QKMTLLMVSHSVEDAARIA..TRSVVVADG MODC_ECOLI/24-205 NGITAIFGVSGAGKTSLINAISGLTR........PQKGRIVLNG....RVLNDAEKGICLTPEKRR..VGYVFQDARLFP..HYKVRGN.LRY.............................................................................................GMSKSMVDQF.........DKLVALLGIE.........PLLDRLPGSLSGGEKQRVAIGRALLTAP...ELLLLDEPLASLDIPRKRELLPYLQRLTRE.INIPMLYVSHSLDEILHLA..DRVMVLENG ARTP_ECOLI/28-217 GETLVLLGPSGAGKSSLLRVLNLLEM........PRSGTLNIAG....NHFDFTKTPSDKAIRDLRRNVGMVFQQYNLWP..HLTVQQN.LIEAPCRV.......................................................................................LGLSKDQALAR........AEKLLERLRLK.........PYSDRYPLHLSGGQQQRVAIARALMMEP...QVLLFDEPTAALDPEITAQIVSIIRELAET..NITQVIVTHEVEVARKTA..SRVVYMENG NASD_KLEOX/34-215 GETISLIGHSGCGKSTLLNLIAGIAL........PTEGGLLCDN....REIAGPG......PERAV.....VFQNHSLLP..WLTCFDN.VALAVDQVF.....................................................................................RRSMSKGERKEW........IEHNLERVQMG.........HALHKRPGEISGGMKQRVGIARALAMKP...KVLLLDEPFGALDALTRAHLQDAVMQIQQS.LNTTIVMITHDVDEAVLLS..DRVLMMTNG FTSE_ECOLI/28-213 GEMAFLTGHSGAGKSTLLKLICGIER........PSAGKIWFSG....HDITRLKN...REVPFLRRQIGMIFQDHHLLM..DRTVYDN.VAIPLII........................................................................................AGASGDDIRRR........VSAALDKVGLL.........DKAKNFPIQLSGGEQQRVGIARAVVNKP...AVLLADEPTGNLDDALSEGILRLFEEFNRV..GVTVLMATHDINLISRRS..YRMLTLSDG NIKE_ECOLI/38-228 GETVALLGRSGCGKSTLARLLVGLES........PAQGNISWRG....EPLAKLNR..AQRKAFRRD.IQMVFQDSISAVNPRKTVREI.LREPMRHL.......................................................................................LSLKKSEQLAR........ASEMLKAVDLDD........SVLDKRPPQLSGGQLQRVCLARALAVEP...KLLILDEAVSNLDLVLQAGVIRLLKKLQQQ.FGTACLFITHDLRLVERFC..QRVMVMDNG PHNC_ECOLI/30-229 GEMVALLGPSGSGKSTLLRHLSGLITG.....DKSVGSHIELLG....RTVQREGRL.ARDIRKSRAHTGYIFQQFNLVN..RLSVLEN.VLIGALGSTPF................................................................................WRTCFSWFTGEQKQR........ALQALTRVGMV.........HFAHQRVSTLSGGQQQRVAIARALMQQA...KVILADEPIASLDPESARIVMDTLRDINQN.DGITVVVTLHQVDYALRYC..ERIVALRQG PSTB_ECOLI/35-227 NQVTAFIGPSGCGKSTLLRTFNKMFELY...PEQRAEGEILLDG....DNILTNS....QDIALLRAKVGMVFQKPTPFP...MSIYDN.IAFGVRLF.......................................................................................EKLSRADMDER........VQWALTKAALWNE.....TKDKLHQSGYSLSGGQQQRLCIARGIAIRP...EVLLLDEPCSALDPISTGRIEELITELKQ...DYTVVIVTHNMQQAARCS..DHTAFMYLG FECE_ECOLI/28-214 GKITALIGPNGCGKSTLLNCFSRLLM........PQSGTVFLGD....NPINMLS.....SRQLARR.LSLLPQHHLTPE..GITVQEL.VSYGRNP........................................................................................WLSLWGRLSAE....DNARVNVAMNQTRIN.........HLAVRRLTELSGGQRQRAFLAMVLAQNT...PVVLLDEPTTYLDINHQVDLMRLMGELRTQ..GKTVVAVLHDLNQASRYC..DQLVVMANG SAPF_ECOLI/40-227 GQTLAIIGENGSGKSTLAKMLAGMIE........PTSGELLIDD....HPLHFGD......YSFRSQRIRMIFQDPSTSLNPRQRISQI.LDFPLRL........................................................................................NTDLEPEQRRKQ.......IIETMRMVGLLP........DHVSYYPHMLAPGQKQRLGLARALILRP...KVIIADEALASLDMSMRSQLINLMLELQEK.QGISYIYVTQHIGMMKHIS..DQVLVMHQG CBIO_SALTY/27-212 SPVTGLVGANGCGKSTLFMNLSGLLR........PQKGAVLWQG....KPLDYSK....RGLLALRQQVATVFQDPEQQI..FYTDIDSDIAFSLRN........................................................................................LGVPEAEITRR........VDEALTLVDAQ.........HFRHQPIQCLSHGQKKRVAIAGALVLQA...RYLLLDEPTAGLDPAGRTQMIAIIRRIVAQ..GNHVIISSHDIDLIYEIS..DAVYVLRQG YTFR_ECOLI/35-221 GEIMALLGENGAGKSTLIKALTGVYH........ADRGTIWLEG....QAISPKNT...AHAQQLG..IGTVYQEVNLLP..NMSVADN.LFIGREPKR.....................................................................................FGLLRRKEMEKR........ATELMASYGFS.........LDVREPLNRFSVAMQQIVAICRAIDLSA...KVLILDEPTASLDTQEVELLFDLMRQLRDR..GVSLIFVTHFLDQVYQVS..DRITVLRNG ARAG_ECOLI/33-219 GQVHALMGENGAGKSTLLKILSGNYA........PTTGSVVING....QEMSFSD.....TTAALNAGVAIIYQELHLVP..EMTVAEN.IYLGQLP...........................................................................................HKGGIVNRS..LLNYEAGLQLKHLGMD.........IDPDTPLKYLSIGQWQMVEIAKALARNA...KIIAFDEPTSSLSAREIDNLFRVIRELRKE..GRVILYVSHRMEEIFALS..DAITVFKDG YHBG_AZOCA/70-253 GEAVGLLGPNGAGKTTVFYMITGLVK........ADQGRIELDG....HDVTPMPM...YRRARLG..IGYLPQEASIFR..GLSVEDN.IGAVLEI........................................................................................TEPNRKRRAEE........LDALLEEFKIT.........HVRKSPSIALSGGERRRVEIARALASRP...AFMLLDEPFAGIDPIAVGDIQALVRHLTTR..GIGVLITDHNVRETLGLI..DRAYIIHSG BRAG_PSEAE/27-209 GEIVTLIGANGAGKSTLLMTLCGSPQ........AASGSIRYEG....EELVGLP.....SSTIMRKSIAVVPEGRRVFS..RLTVEEN.LAMGGFF..........................................................................................TDKDDYQVQ........MDKVLELFPRLK........ERYEQRAGTMSGGEQQMLAIGRALMSKP...KLLLLDEPSLGLAPIIIQQIFEIIEQLRRE..GVTVFLVEQNANQALKLA..DRAYVLENG BRAF_PSEAE/31-230 KQVVSMIGPNGAGKTTVFNCLTGFYQ........PTGGLIRLDG....EEIQGLPG...HKIARKG..VVRTFQNVRLFK..EMTAVEN.LLVAQHRHLNTN...............................................................................FLAGLFKTPAFRRSER..EAMEYAAHWLEEVNLT.........EFANRSAGTLAYGQQRRLEIARCMMTRP...RILMLDEPAAGLNPKETDDLKALIAKLRSE.HNVTVLLIEHDMKLVMSIS..DHIVVINQG YHIH_ECOLI/21-207 RCMVGLIGPDGVGKSSLLSLISGARV........IEQGNVMVLG....GDMRDPK....HRRDVCPR.IAWMPQGLGKNLYHTLSVYEN.VDFFARL........................................................................................FGHDKAEREVR........INELLTSTGLA.........PFRDRPAGKLSGGMKQKLGLCCALIHDP...ELLILDEPTTGVDPLSRSQFWDLIDSIRQRQSNMSVLVATAYMEE.AERF..DWLVAMNAG NOSF_PSEST/29-204 GEVLGLFGHNGAGKTTSMKLILGLLS........PSEGQVKVLG....R..APND......PQVRRQ.LGYLPENVTFYP..QLSGRET.LRHFARL............................................................................................KGAALTQ........VDELLEQVGLA.........HAADRRVKTYSKGMRQRLGLAQALLGEP...RLLLLDEPTVGLDPIATQDLYLLIDRLRQR..GTSIILCSHVLPGVEAHI..NRAAILAKG NODI_AZOCA/40-221 GERYGIMGTNGAGKSSLINIILGLTP........PDRGTVTVFG....KDMRRQG.....HLARAR..IGVVPQDDCLEQ..NMTPYEN.VMLYGRL........................................................................................CRMTASEARKR........ADQIFEKFSMM.........DCANRPVRLLSGGMRRLTMVARALVNDP...YVIILDEATVGLDAKSRSALWQQIEASNAT..GATVLVISHLAEDLERMT..DRIACICAG ABC1_MOUSE/926-1107 GQITSFLGHNGAGKTTTMSILTGLFP........PTSGTAYILG....KDIRSEM.......SSIRQNLGVCPQHNVLFD..MLTVEEH.IWFYARL........................................................................................KGLSEKHVKAE........MEQMALDVGLPP........SKLKSKTSQLSGGMQRKLSVALAFVGGS...KVVILDEPTAGVDPYSRRGIWELLLKY.RQ..GRTIILSTHHMDEADILG..DRIAIISHG PHNK_ECOLI/31-222 GEVLGIVGESGSGKTTLLKSISARLT........PQQGEIHYEN....RSLYAMSE..ADRRRLLRTEWGVVHQHPLDGLRRQVSAGGN.IGERLMA...........................................................................................TGARHYGD....IRATAQKWLEEVEIPA........NRIDDLPTTFSGGMQQRLQIARNLVTHP...KLVFMDEPTGGLDVSVQARLLDLLRGLVVE.LNLAVVIVTHDLGVARLLA..DRLLVMKQG AMIE_STRPN/38-236 GEVLALVGESGSGKSVLTKTFTGMLEEN....GRIAQGSIDYRG....QDLTALSSH.KDWEQIRGAKIATIFQDPMTSLDPIKTIGSQ.ITEVIVKH.......................................................................................QGKTAKEAKEL........AIDYMNKVGIPD......ADRRFNEYPFQYSGGMRQRIVIAIALACRP...DVLICDEPTTALDVTIQAQIIDLLKSLQNE.YHFTTIFITHDLGVVASIA..DKVAVMYAG NIKD_ECOLI/29-217 GRVLALVGGSGSGKSLTCAATLGILPAG....VRQTAGEILADG....KPVSPCA........LRGIKIATIMQNPRSA...FNPLHTM.HTHARET........................................................................................CLALGKPADDA.......TLTAAIEAVGLEN......AARVLKLYPFEMSGGMLQRMMIAMAVLCES...PFIIADEPTTDLDVVAQARILDLLESIMQK.QAPGMLLVTHDMGVVARLA..DDVAVMSDG SAPD_SALTY/33-235 GEIRGLVGESGSGKSLIAKAICGVAKDN....WRVTADRMRFDD....IDLLRLSS..RERRKLVGHNVSMIFQEPQSCLDPSERVGRQ.LMQNIPA..........................................................................................WTYKGRWWQRLGWRKRRAIELLHRVGIKD......HKDAMRSFPYELTDGECQKVMIAIALANQP...RLLIADEPTNSMEPTTQAQIFRLLTRLNQN.SNTTILLISHDLQMLSQWA..DKINVLYCG YYBJ_BACSU/27-204 GTIYGLFGSNGSGKTMLLRALSGLIV........PTEGSITIKG....EQLHKDISF.PKSVGLIIENM....QLLP.....QYDAFTN.LKILSKI...........................................................................................KKIASDND........ILDSISRVGLE.........NFNSVKVSKFSLGMKQRLNIAQAIFEKP...DILLLDEPTNAIDEKGVAFVHDILLQEKKR..GATIIITSHHKEDIISLC..DIALEMNHG PHNL_ECOLI/34-223 GECVVLHGHSGSGKSTLLRSLYANYL........PDEGQIQIKHGDEWVDLVTAPA..RKVVEIRKTTVGWVSQFLRVIP..RISALEV.VMQPLLD........................................................................................TGVPREACAAK........AARLLTRLNVPE........RLWHLAPSTFSGGEQQRVNIARGFIVDY...PILLLDEPTASLDAKNSAAVVELIREAKTR..GAAIVGIFHDEAVRNDVA..DRLHPM..G SYRD_PSESY/373-551 GELVYIVGGNGCGKSTLAKVFCGLYI........PQEGQLLLDG....AAVTDDS...............RGDYRDLFSAVFSDFHLFN.RLIGPD...........................................................................................EKEHPSTDQ........AQTYLSTLGLEDKV...KIEGLGYSTTTALSYGQQKRLALVCAYLEDR...PIYLLDEWAADQDPPFKRFFYEELLPDLKR.RGKTILIITHDDQY.FQLA..DRIIKLADG ABCA_AERSA/51-221 GETIGIVGHNGAGKSTLLQLITGVMQ........PDCGQITRTG....R.VVGLL........E.........LGSGFNP..EFTGREN.IFFNGAI........................................................................................LGMSQREMDDR........LERILSFAAIG.........DFIDQPVKNYSSGMMVRLAFSVIINTDP...DVLIIDEALAVGDDAFQRKCYARLKQLQSQ..GVTILLVSHAAGSVIELC..DRAVLLDRG YJJK_ECOLI/348-516 GAIVGIIGPNGAGKSTLFRMISGQEQ........PDSGTITLGE....TVKLAS.................VDQFRDSMDN.SKTVWEE.VSGGLDI........................................................................................MKIGNTEMPSR......AYVGRF..NFKGV..........DQGKRVGELSGGERGRLHLAKLLQVGG...NMLLLDEPTNDLDIETLRALENALLEF.....PGCAMVISHDRWFLDRIA..THILDYQDE YJJK_ECOLI/31-234 GAKIGVLGLNGAGKSTLLRIMAGIDK........DIEGEARPQP...................DIK..IGYLPQEPQLNP..EHTVRES.IEEAVSEVVNALKRLDEVYALYADPDA.................................................DFDKLAAEQGRLEEIIQAHDGHNLNVQLER........AADA...LRLP..........DWDAKIANLSGGERRRVALCRLLLEKP...DMLLLDEPTNHLDAESVAWLERFLHDF.....EGTVVAITHDRYFLDNVA..GWILELDRG TLRC_STRFR/380-542 AERLLITGPNGAGKSTLLSVLAGELS........PDAGAVSVPG.......................RVGHLRQEETPWP.AKLTVLEA.FAHNRPG...........................................................................................DRDEQADR........RLSL..GLFEP.........EALRLRVGELSYGQRRRIELARLVSEPV...GLLLLDEPTNHLSPALVEELEEALTGY.....GGALVLVTHDRRMRSRFT..GSHLELREG TLRC_STRFR/34-241 GEKAGIIGDNGAGKSTLLRLLAGEER........PDAGEVTVIA....PGGVGYL......PQTLGLPPRATVQDAIDL...AMTELRV.LEAELRRTEAALAEAATD..................................................................EALQDALTAYARLTEQYEVRDGY..GADARVDAALHGLGLPG........LPRDRRLGTLSGGERSRLALAATLASQP...ELLLLDEPTNDLDDRAVHWLEEHLSGH.....RGTVVTVTHDRVFLDRLT..ATVLEVDGR MSRA_STAEP/31-175 FEKIALIGGNGTGKTTLLNMIAQKTK........PESGTVETNG......................................EIQYFEQ.LNM..............................................................................................DVENDFNTL........DGSLMSELHIP...........MHT.TDSMSGGEKAKYKLANVISNYS...PILLLDEPTNHLDKIGKDYLNNILKYY.....YGTLIIVSHDRALIDQIA..DTIWDIQED EXPZ_BACSU/317-480 GEKVAIIGPNGSGKTTLLNIILGQET.........AEGSVWVSP....S..ANIG........YLT.......QEVFDLP......LEQ.TPEELFE..........................................................................................NETFKARGH........VQNLMRHLGFTA........AQWTEPIKHMSMGERVKIKLMAYILEEK...DVLILDEPTNHLDLPSREQLEETLSQY.....SGTLLAVSHDRYFLEKTT.NSKLVISNNG YEM6_YEAST/421-588 DSRIALVGPNGVGKSTLLKIMTGELT........PQSGRVSRHT....H..VKLG......VYSQH......SQDQLDL...TKSALEF.VRDKYSN..........................................................................................ISQDFQFWR.......GQLGRYGLTGEG...........QTVQMATLSEGQRSRVVFALLALEQP...NVLLLDEPTNGLDIPTIDSLADAINEF.....NGGVVVVSHDFRLLDKIA..QDIFVVENK MSRA_STAEP/324-482 GKNIALVGANGVGKTTLLEAIYHQIE........GIDCSPKVQMA.........................YYRQLAYEDM......RDV.SLLQYLM..........................................................................................DETDSSESF........SRAILNNLGLN.........EALERSCNVLSGGERTKLSLAVLFSTKA...NMLILDEPTNFLDIKTLEALEMFMNKY.....PGIILFTSHDTRFVKHVS..DKKWELTGQ YEM6_YEAST/107-299 GRRYGLLGENGCGKSTFLKALATREYP......IPEHIDIYLLD....EPAEPSE......LSALDYVVTEAQHELKRI...EDLVEKT.ILEDGPESELLE...............................................................................PLYERMDSLDPDTFE........SRAAIILIGLGF......NKKTILKKTKDMSGGWKMRVALAKALFVKP...TLLLLDDPTAHLDLEACVWLEEYLKRF.....DRTLVLVSHSQDFLNGVC..TNMIDMRAQ EF3_CANAL/458-620 NRRYGLCGPNGAGKSTLMRAIANGQV..........EGFPTQDE....C..KTVY......VEHDI........DGTHA...DTTVVEF.VIEDGEV.........................................................................................GLTKDVVVDK........LREF..NFSDE..........MINMPIQSLSGGWKMKLALARAVLKNA...DILLLDEPTNHLDTVNVAWLVNYLNTC.....GITSIIVSHDSGFLDNVT..QYIIHYEGF EF3_CANAL/698-973 SSRIAVIGPNGAGKSTLINVLTGELL........PTTGEFYVHE....NCRIAYIK..QHAFAHIDNHLDKTPSEYIQWRFQTGEDRET.MDRASRQINEEDEQNMNKIFKIEGTPRRIAGIHARRKFKNSYEYEISWMLGENIGMKNERWVPMMSVDNTWLPRGELMETHAKLVAEVDMKEALASGQFRPLTRKE........IEEHCAMLGLDA.......ELVSHSRIRGLSGGQKVKLVLAACTWQRP...HLIVLDEPTNYLDRDSLGALSKALKAF.....EGGIVIITHSAEFTKDLT..EEVWAVLDG YDDA_ECOLI/393-560 GKWLLLKGYSGAGKTTLLKTLSHCWP........WFKGDISSPA....DSWYVS...................QTPLIK...TGLLKEI.ICKALPL............................................................................................PVDDKSL.........SEVLHQVGLGKLA...ARIHDHDRWGDILSSGEKQRIALARLILRRP...KWIFLDETTSHLEEQEAIRLLRLVREKLP...TSGVIMVTHQPGV.WNLA..DDICDISAV CCMA_RHOCA/29-191 GHALVLRGPNGIGKTTLLRTLAGLQP........PLAGRVSMPP....EGIAYAA........HAD..........GLKA..TLSVREN.LQFWAAI.............................................................................................HATDTV.........ETALARMNLN.........ALEHRAAASLSAGQKRRLGLARLLVTGR...PVWVLDEPTVSLDAASVALFAEAVRAHLAA..GGAALMATHIDLG.LSEA...RVLDLAPF CCMA_ECOLI/29-204 GEWVQITGSNGAGKTTLLRLLTGLSR........PDAGEVLWQG....QPLHQVRD..SYHQNLLW.....IGHQPGIKT..RLTALEN.LHFYHRD..............................................................................................GDTAQ........CLEALAQAGLA.........GFEDIPVNQLSAGQQRRVALARLWLTRA...TLWILDEPFTAIDVNGVDRLTQRMAQHTEQ..GGIVILTTHQPLNVAESK..IRRISLTQT MODF_ECOLI/286-479 GEHWQIVGPNGAGKSTLLSLVTGDHP.......QGYSNDLTLFG....R..RRGSG...ETIWDIKKHIGYVSSSLHLDYRVSTTVRNV.ILSGYFDSI....................................................................................GIYQAVSDRQQKL........VQQWLDILGIDK........RTADAPFHSLSWGQQRLALIVRALVKHP...TLLILDEPLQGLDPLNRQLIRRFVDVLISE.GETQLLFVSHHAEDAPACI.THRLEFVPDG YMEB_LACLA/29-219 GENWVILGLNGSGKSSLLKLILAEEW........KTSGEITVLN....T..QFGN....GEIPKLRKRISVVGSFIAERFQPNIKAENL.VYTGKFN........................................................................................SSMLYKPYTDQ....ELDEARQLLRQMGAK.........SLIGRNYASLSQGEKQVLLIARSLILKP...ELLILDEATNGLDLFAKEKLLKQLQQINQLKTAPTLIYISHHPDEITDIF..THLLLLREG CFTR_BOVIN/450-621 GQLLAVAGSTGAGKTSLLLMIMGELE........ASEGKIKHSG....R.ISFCS......QYSWI........MPGTI.......KDN.IIFGVSY...........................................................................................DEYRYRSVI...KACQLEEDISKFAEKD.......NVVLGEGGITLSGGQRARISLARAVYKDA...DLYLLDSPFGYLDVLTEKEIFESCICKLMA..NKTRILVTSKMEH.LKKA..DKILILHEG UVRA_MICLU/685-956 GVLTAVTGVSGSGKSTLINEILYKVLA......NRLNGAKLVPG....RHRSVEG......LEHLDK.VVHVDQSPIGRTPRSNPATYT.GVFDAIRKLFAETPEAKVRGYQQGRFSFNIKGGRCEACAGDGTLKIEMNF...LPDVYVPCEVCHGARYNRETLEVTYKGKNIAEVLDMPIEEAADFFSAYTRISR........YLDTLVDVGLGY........VRLGQPATTLSGGEAQRVKLAAELQKRSNGRTIYVLDEPTTGLHFDDIRKLLHVLQSLVDK..GNTVLTIEHNLDV.IKSA..DHVIDL..G UVRA_ECOLI/633-905 GLFTCITGVSGSGKSTLINDTLFPIAQRQLNGATIAEPAPYRDI....QGLEHFD...KVIDIDQSPIGRTPRSNPATYTGVFTPVREL.FAGVPESRARGYTPGRFSFNVRGGRCEACQGDGVIKVEMHFLP.................DIYVPCDQCKGKRYNRETLEIKYKGKTIHEVLDMTIEEAREFFDAVP...ALARKLQTLMDVGLTY........IRLGQSATTLSGGEAQRVKLARELSKRGTGQTLYILDEPTTGLHFADIQQLLDVLHKLRDQ..GNTIVVIEHNLDV.IKTA..DWIVDL..G P29_MYCHR/35-229 DKVLFLLGSSGQGKSSLLKTILKQTD........VIEGTILFNK....QDIFQLNK..KEWKSFLKE.VSFLNQTTTSIP..FETVFTN.IVRSLQDYK.....................................................................................NLFYNIFNLVSKS...QKEEITSVLKELNIL.........DKIYHRVDSLSGGQQQRVEIAKLMMQKP...KIIIADEPTNFLDPNISKNIIELIIKMAKK.FNSILIIVTHNVNLIHEFD..SSILLIKNQ ABCX_ANTSP/32-227 GEIHAIMGKNGSGKSTLAKVIAGHPSY......KITNGQILFEN....QDVTEIEP...EDRSHLG..IFLAFQYPVEIPGVTNADFLR.IAYNAKR........................................................................................AFDNKEELDPLS...FFSFIENKISNIDLNS.......TFLSRNVNEGFSGGEKKKNEILQMSLLNS...KLAILDETDSGLDIDALKTIAKQINSLKTQ..ENSIILITHYQRLLDYIK.PDYIHVMQKG PDR5_YEAST/186-386 GELLVVLGRPGSGCTTLLKSISSNTHGF....DLGADTKISYSG....YSGDDIK......KHFRGE.VVYNAEADVHLP..HLTVFET.LVTVARL.........................................................................................KTPQNRIKGVD...RESYANHLAEVAMATYGLSHTRNTKVGNDIVRGVSGGERKRVSIAEVSICGS...KFQCWDNATRGLDSATALEFIRALKTQADI..SNTSATVAIYQCSQDAYDLFNKVCVLDDG ADP1_YEAST/416-607 GQILAIMGGSGAGKTTLLDILAMKRKT......GHVSGSIKVNG....ISMDRKS.......FSKI..IGFVDQDDFLLP..TLTVFET.VLNSALL..........................................................................................RLPKALSFEA...KKARVYKVLEELRIIDI....KDRIIGNEFDRGISGGEKRRVSIACELVTSP...LVLFLDEPTSGLDASNANNVIECLVRLSSD.YNRTLVLSIHQPRSNIFYL.FDKLVLLSKG ALD_HUMAN/500-677 GMHLLITGPNGCGKSSLFRILGGLWP........TYGGVLYKPP....PQRMFYIP.................QRPYMS...VGSLRDQ.VIYPDSVEDM...................................................................................QRKGYSEQDLEAIL...DVVHLHHILQREGGW.........EAMCDWKDVLSGGEKQRIGMARMFYHRP...KYALLDECTSAVSIDVEGKIFQAAKDA.....GIALLSITHRPSLWKYHT..HLLQFDGEG MCBF_ECOLI/33-210 GELIGLLGENPAGKTTLFNLIRGGVS........NYEGTLKRNF....SGGELVS.....LPQVIN.......LSGTLR...NEEVLDL.ICCFNKL..........................................................................................TKKQAWTDV........NHKWNDNFFIRY.......DKIRRKRTYTVSYGEKRWLIISLMVTLCKN.ARLFLLDEPTVGIDIQYRMMLWELINKITAD..GKTVFFSTHIFDELTRDK..IPFYMLSKN