TTK_HUMAN/509-775 YSILKQIGSGGSSKV..FQVLNEKKQI.........YAIKYVNLEEADNQTLDSYRN...................EIAYLNKLQQ..HSDKI..IRLYDYEIT..................DQYIY..MVMECGNI......DLN..SWLK................KKKSI...DPWERKSYWKNMLEAVHTIHQ.H..........GIVHSDLKPANFLIV..DGML...................KLIDFGIANQMQ...............PDTTSV.VKDSQVGTVNYMPP....EA....IKDMSSS....RENGKSKSKISPKSDVWSLGCILYYMTY.....GK......TPFQ.QI.......INQISKLHAIIDPNHEIEFPDIPE.........................................KDLQDVLKCCLKRDPKQRIS.....IPELLAHPYV CLK1_MOUSE/160-476 YEIVDTLGEGAFGKVVECIDHKVGGRR.........VAVKIVKNVDRYCEAAQS......................EIQVLEHLNTTDPHSTFRCVQMLEWFEH..................RGHIC..IVFELL........GLSTYDFIK.................ENSFLPFRMDHIRKMAYQICKSVNFLHS.N..........KLTHTDLKPENILFV.KSDYTEAYNPKMKRDERTIVNPDIKVVDFGSA....................TYDDE.HHSTLVSTRHYRAP....EV....IL...............ALGWSQPCDVWSIGCILIEYYL.....GF......TVFP.TH.....DSREHLAMMERILGPLPKHMIQKTRKRRYFHHDRLDWDEHSSAGRY..VSRRCKPLKEFMLSQDAEHEFLFDLVGKILEYDPAKRIT.....LKEALKHPFF FUSE_DROME/4-254 YAVSSLVGQGSFGCV..YKATRKDDSK........VVAIKVISKRGRATKELKNLRR...................ECDIQARL.K...HPHV..IEMIESFES..................KTDLF..VVTEFALM......DLH..RYLS................YNGAM...GEEPARRVTGHLVSALYYLHS.N..........RILHRDLKPQNVLLD.KNMHA...................KLCDFGLARNM.................TLGTH.VLTSIKGTPLYMAP....EL....LA...............EQPYDHHADMWSLGCIAYESMA.....GQ......PPFC.AS........SILHLVKMIKHEDVKWPSTLT...........................................SECRSFLQGLLEKDPGLRIS.....WTQLLCHPFV KAKT_MLVAT/171-429 FEYLKLLGKGTFGKV..ILVKEKATGR........YYAMKILKKEVIVAKDEVAHTLT..................ENRVLQNS.R...HPFL..TALKYSFQT..................HDRLC..FVMEYANGG.....ELF..FHLS................RERVF...SEDRARFYGAEIVSALDYLHSEK..........NVVYRDLKLENLMLD.KDGHI...................KITDFGLCKEG.................IKDGA.TMKTFCGTPEYLAP....EV....LE...............DNDYGRAVDWWGLGVVMYEMMC.....GR......LPFY.NQ........DHEKLFELILMEEIRFPRTLG...........................................PEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFF KI82_YEAST/324-602 FEKIRLLGQGDVGKV..YLMRERDTNQ........IFALKVLNKHEMIKRKKIKRVLT..................EQEILATS.D...HPFI..VTLYHSFQT..................KDYLY..LCMEYCMGG.....EFF..RALQ..............TRKSKCI...AEEDAKFYASEVVAALEYLHL.L..........GFIYRDLKPENILLH.QSGHV...................MLSDFDLSIQATGSKKPTMKDSTYLDTKICSDGFRTNSFVGTEEYLAP....EV....IR...............GNGHTAAVDWWTLGILIYEMLF.....GC......TPFK.GD........NSNETFSNILTKDVKFPHDKEVS.........................................KNCKDLIKKLLNKNEAKRLGSK.SGAADIKRHPFF PKD1_DICDI/36-291 FNFYGSLGSGSFGTA..KLCRHRGSGL........FFCSKTLRRETIVHEKHKEHVNN..................EINIMLNI.S...HPYI..VKTYSTFNT..................PTKIH..FIMEYAGKK.....DLF..HHLR................ANKCF...TEQTTKLIVAEIVLAIEYLHA.E..........NIIYRDLKPENILID.EKGHI...................KLTDFGFSKK..................TVGGK.NTSSVCGTFDYMAP....EI....LN..............SSNGHGKPVDWWALGVVVYELVT.....GK......LPFS.NSKESLLNRKADFQLIFQNSYLS...................................................DEIKDFIFQLLSVDPSKRLGT..FDSCSIRNHKWF KGP1_DROME/457-717 LEVVSTLGIGGFGRVELVKAHHQDRVD........IFALKCLKKRHIVDTKQEEHIFS..................ERHIMLSS.R...SPFI..CRLYRTFRD..................EKYVY..MLLEACMGG.....EIW..TMLR................DRGSF...EDNAAQFIIGCVLQAFEYLHA.R..........GIIYRDLKPENLMLD.ERGYV...................KIVDFGFAKQ..................IGTSS.KTWTFCGTPEYVAP....EI....IL...............NKGHDRAVDYWALGILIHELLN.....GT......PPFS.AP........DPMQTYNLILKGIDMIAFPKHIS.........................................RWAVQLIKRLCRDVPSERLGYQTGGIQDIKKHKWF ARK1_BOVIN/191-453 FSVHRIIGRGGFGEV..YGCRKADTGK........MYAMKCLDKKRIKMKQGETLAL...................NERIMLSLVSTGDCPFI..VCMSYAFHT..................PDKLS..FILDLMNGG.....DLH..YHLS................QHGVF...SEADMRFYAAEIILGLEHMHN.R..........FVVYRDLKPANILLD.EHGHV...................RISDLGLAC...................DFSKK.KPHASVGTHGYMAP....EV....LQ..............KGVAYDSSADWFSLGCMLFKLLR.....GH......SPFR.QH.....KTKDKHEIDRMTLTMAVELPDSFS...........................................PELRSLLEGLLQRDVNRRLGCLGRGAQEVKESPFF CHK1_SCHPO/10-272 YHIGREIGTGAFASV..RLCYDDNAKI.........YAVKFVNKKHATSCMNAGVWARR..............MASEIQLHKLCNG...HKNI..IHFYNTAEN..................PQWRW..VVLEFAQGG.....DLF..DKIE................PDVGI...DEDVAQFYFAQLMEGISFMHS.K..........GVAHRDLKPENILLD.YNGNL...................KISDFGFASLFS...............YKGKSR.LLNSPVGSPPYAAP....EI....................TQQYDGSKVDVWSCGIILFALLL.....GN......TPWD.EA.....ISNTGDYLLYKKQCERPSYHPWNLLS.........................................PGAYSIITGMLRSDPFKRYS.....VKHVVQHPWL CDC5_YEAST/82-337 YHRGHFLGEGGFARC..FQIKDDSGEI.........FAAKTVAKASIKSEKTRKKLLS..................EIQIHKSM.S...HPNI..VQFIDCFED..................DSNVY..ILLEICPNG.....SLM..ELLK................RRKVL...TEPEVRFFTTQICGAIKYMHS.R..........RVIHRDLKLGNIFFD.SNYNL...................KIGDFGLAAVL.................ANESE.RKYTICGTPNYIAP....EV....LM.............GKHSGHSFEVDIWSLGVMLYALLI.....GK......PPFQ.AR........DVNTIYERIKCRDFSFPRDKPIS.........................................DEGKILIRDILSLDPIERPS.....LTEIMDYVWF RA53_YEAST/198-466 SIIDEVVGQGAFATV..KKAIERTTGK........TFAVKIISKRKVIGNMDGVTR....................ELEVLQKL.N...HPRI..VRLKGFYED..................TESYY..MVMEFVSGG.....DLM..DFVA................AHGAV...GEDAGREISRQILTAIKYIHS.M..........GISHRDLKPDNILIEQDDPVL..................VKITDFGLAKV..................QGNGS.FMKTFCGTLAYVAP....EV....IRGKDTSV..SPDEYEERNEYSSLVDMWSMGCLVYVILT.....GH......LPFS.GS........TQDQLYKQIGRGSYHEGPLKDFRIS.......................................EEARDFIDSLLQVDPNNRST.....AAKALNHPWI KPK2_PLAFK/111-364 YVLNKKIGKGSFSTA..YIGTNILYGN........RVVVKEVDKSKVKESNVYT......................EIEVLRKV.M...HKYI..IKLISAYEQ..................EGFVY..LVLEYLKGG.....ELF..EYLN................NNGPY...TEQVAKKAMKRVLIALEALHS.N..........GVVHRDLKMENLMLE..NPNDPS...............SLKIIDFGLAS...................FLNSP.SMNMRCGSPGYVAP....EI....LK...............CASYGTKVDIFSLGVILFNILC.....GY......PPFR.GN........NVKEIFKKNMRCHISFNTKHWINKS.......................................ESVKEIILWMCCKNPDDRCT.....ALQALGHQWF K6A1_MOUSE/407-664 YVVKETIGVGSYSVC..KRCVHKATNM........EYAVKVIDKSKRDPSE.........................EIEILLRYGQ...HPNI..ITLKDVYDD..................GKHVY..LVTELMRGG.....ELL..DKIL................RQKFF...SEREASFVLHTISKTVEYLHS.Q..........GVVHRDLKPSNILYV.DESGNPE...............CLRICDFGFAKQL.................RAENG.LLMTPCYTANFVAP....EV....LK...............RQGYDEGCDIWSLGILLYTMLA.....GY......TPFA.NG.....PSDTPEEILTRIGSGKFTLSGGNWNTVS.......................................ETAKDLVSKMLHVDPHQRLT.....AKQVLQHPWI KPBH_RAT/24-291 YDPKDIIGRGVSSVV..RRCVHRATGD........EFAVKIMEVSAERLSLEQLEEVRDA.............TRREMHILRQVAG...HPHI..ITLIDSYES..................SSFMF..LVFDLMRKG.....ELF..DYLT................EKVAL...SEKETRSIMRSLLEAVNFLHV.N..........NIVHRDLKPENILLD.DNMQI...................RLSDFGFSCH..................LEPGE.KLRELCGTPGYLAP....EI....LKCS.........MDETHPGYGKEVDLWACGVILFTLLA.....GS......PPFW.HR........RQILMLRMIMEGQYQFSSPEWDDRS.......................................NTVKDLIAKLLQVDPNARLT.....AEQALQHPFF KCC4_MOUSE/42-296 FEVESELGRGATSIV..YRCKQKGTQK........PYALKVLKKTVDKKIVRT.......................EIGVLLRL.S...HPNI..IKLKEIFET..................PTEIS..LVLELVTGG.....ELF..DRIV................EKGYY...SERDARDAVKQILEAVAYLHE.N..........GIVHRDLKPENLLYA..TPAPDA...............PLKIADFGLSKI..................VEHQV.LMKTVCGTPGYCAP....EI....LR...............GCAYGPEVDMWSVGIITYILLC.....GF......EPFY.DE.......RGDQFMFRRILNCEYYFISPWWDEVS.......................................LNAKDLVKKLIVLDPKKRLT.....TFQALQHPWV CDPK_SOYBN/34-292 YEVGRKLGQGQFGTT..FECTRRASGG........KFACKSIPKRKLLCKEDYEDVWR..................EIQIMHHLSE...HANV..VRIEGTYED..................STAVH..LVMELCEGG.....ELF..DRIV................QKGHY...SERQAARLIKTIVEVVEACHS.L..........GVMHRDLKPENFLFD..TIDEDA...............KLKATDFGLSVF..................YKPGE.SFCDVVGSPYYVAP....EV....LR................KLYGPESDVWSAGVILYILLS.....GV......PPFW.AE........SEPGIFRQILLGKLDFHSEPWPSIS.......................................DSAKDLIRKMLDQNPKTRLT.....AHEVLRHPWI KMLS_CHICK/1453-1708 YNIEERLGSGKFGQV..FRLVEKKTGK........VWAGKFFKAYSAKEKENIRD.....................EISIMNCL.H...HPKL..VQCVDAFEE..................KANIV..MVLEMVSGG.....ELF..ERII...............DEDFEL...TERECIKYMRQISEGVEYIHK.Q..........GIVHLDLKPENIMCV.NKTGTS.................IKLIDFGLARR..................LESAG.SLKVLFGTPEFVAP....EV....IN...............YEPIGYETDMWSIGVICYILVS.....GL......SPFM.GD........NDNETLANVTSATWDFDDEAFDEIS.......................................DDAKDFISNLLKKDMKSRLN.....CTQCLQHPWL KIN1_SCHPO/125-395 YVLGKTIGAGSMGKV..KVAHHLKTGE........QFAIKIVTRLHPDITKAKAAASAEATKAAQSEKNKEIRTVREAALSTLL.R...HPYI..CEARDVYIT..................NSHYY..MVFEFVDGG.....QML..DYII................SHGKL...KEKQARKFVRQIGSALSYLHQ.N..........SVVHRDLKIENILIS.KTGDI...................KIIDFGLSNL..................YRRQS.RLRTFCGSLYFAAP....EL....LN..............AQPYIGPEVDVWSFGIVLYVLVC.....GK......VPFD.DQ........NMSALHAKIKKGTVEYPSYLS...........................................SDCKGLLSRMLVTDPLKRAT.....LEEVLNHPWM CDR1_SCHPO/12-258 WRLGKTLGTGSTSCV..RLAKHAKTGD........LAAIKIIPIRYASIGM.........................EILMMRLL.R...HPNI..LRLYDVWTD..................HQHMY..LALEYVPDG.....ELF..HYIR................KHGPL...SEREAAHYLSQILDAVAHCHR.F..........RFRHRDLKLENILIKVNEQQI...................KIADFGMATV..................EPNDS.CLENYCGSLHYLAP....EI....VS..............HKPYRGAPADVWSCGVILYSLLS.....NK......LPFG.GQ........NTDVIYNKIRHGAYDLPSSIS...........................................SAAQDLLHRMLDVNPSTRIT.....IPEVFSHPFL MEK1_YEAST/162-444 EITNRIVGNGTFGHV..LITHNSKERDEDVCYHPENYAVKIIKLKPNKFDK.........................EARILLRL.D...HPNI..IKVYHTFCD.................RNNHLY..IFQDLIPGG.....DLF..SYLA................KGDCLTSMSETESLLIVFQILQALNYLHD.Q..........DIVHRDLKLDNILLC..TPEPCT...............RIVLADFGIAKDL.................NSNKE.RMHTVVGTPEYCAP....EVGFRANRKAYQSF..SRAATLEQRGYDSKCDLWSLGVITHIMLT.....GI......SPFY.GD.......GSERSIIQNAKIGKLNFKLKQWDIVS.......................................DNAKSFVKDLLQTDVVKRLN.....SKQGLKHIWI PIM1_HUMAN/38-290 YQVGPLLGSGGFGSV..YSGIRVSDNL........PVAIKHVEKDRISDWGELPNGTRV...............PMEVVLLKKVSS..GFSGV..IRLLDWFER..................PDSFV..LILERPEPVQ....DLF..DFIT................ERGAL...QEELARSFFWQVLEAVRHCHN.C..........GVLHRDIKDENILID.LNRGE..................LKLIDFGSGA...................LLKDT.VYTDFDGTRVYSPP....EW....IR..............YHRYHGRSAAVWSLGILLYDMVC.....GD......IPFE.HD.....EEIIRGQVFFRQRVS....................................................SECQHLIRWCLALRPSDRPT.....FEEIQNHPWM KAB7_YEAST/1096-1354 FVSLQKMGEGAYGKV..NLCIHKKNRY........IVVIKMIFKERILVDTWVRDRKLGT.............IPSEIQIMATL.NKKPHENI..LRLLDFFED..................DDYYY....IETPVHGETGCIDLF..DLIE................FKTNM...TEFEAKLIFKQVVAGIKHLHD.Q..........GIVHRDIKDENVIVD.SKGFV...................KIIDFGSAA...................YVKSG.PFDVFVGTIDYAAP....EV....LG..............GNPYEGQPQDIWAIGILLYTVVF.....KE......NPFY...............NIDEILEGDLKFNNAEEVS.........................................EDCIELIKSILNRCVPKRPT.....IDDINNDKWL KC21_CHICK/39-324 YQLVRKLGRGKYSEV..FEAINITNNE........KVVVKILKPVKKKKIKR........................EIKILENLRG...GPNI..ITLADIVKDP................VSRTPA..LVFEHVNNT.....DFK.....................QLYQTL...TDYDIRFYMYEILKALDYCHS.M..........GIMHRDVKPHNVMID.HEHRK..................LRLIDWGLAEF..................YHPGQ.EYNVRVASRYFKGP....EL....LV..............DYQMYDYSLDMWSLGCMLASMIF.....RK......EPFF.HG....HDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSR.........KRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLT.....AREAMEHPYF MK04_HUMAN/20-312 FVDFQPLGFGVNGLV..LSAVDSRACR........KVAVKKIALSDARSMKHALR.....................EIKIIRRL.D...HDNI..VKVYEVLGPKGTDL.......QGELFKFSVAY..IVQEYMETDLARLLEQG.........................TL...AEEHAKLFMYQLLRGLKYIHS.A..........NVLHRDLKPANIFIS.TEDLV..................LKIGDFGLARIVD..............QHYSHKG.YLSEGLVTKWYRSP....RL....LL..............SPNNYTKAIDMWAAGCILAEMLT.....GR......MLFA.GA.....HELEQMQLILETIPVIREEDKDELLRVMPSFVSSTWEV.................KRPLRKLLPEVNSEAIDFLEKILTFNPMDRLT.....AEMGLQHPYM ERK1_CANAL/68-371 YQILEIVGEGAYGIV..CSAIHKPSQQ........KVAIKKIEPFERSMLCLRTLR....................ELKLLKHF.N...HENI..ISILAIQRPIN.............YESFNEIY..LIQELMETDLHRVIRTQ.........................NL...SDDHIQYFIYQTLRALKAMHS.A..........NVLHRDLKPSNLLLN.SNCDL...................KICDFGLARSIA..............SQEDNYG.FMTEYVATRWYRAP....EI....ML..............TFQEYTTAIDVWSVGCILAEMLS.....GR......PLFP.GR.....DYHNQLWLIMEVLGTPNMEDYYNIKSKRAREYIRSLPFCKKIPFSELFANTNNNTSTSNTGGRTNINPLALDLLEKLLIFNPAKRIT.....VEDALKHPYL KKIA_HUMAN/5-288 YEKIGKIGEGSYGVV..FKCRNRDTGQ........IVAIKKFLESEDDPVIKKIALR...................EIRMLKQL.K...HPNL..VNLLEVFRR..................KRRLH..LVFEYCDHTVLHELDRY.......................QRGV...PEHLVKSITWQTLQAVNFCHK.H..........NCIHRDVKPENILIT.KHSVI...................KLCDFGFARLL.................TGPSD.YYTDYVATRWYRSP....EL....LV..............GDTQYGPPVDVWAIGCVFAELLS.....GV......PLWP.GK.....SDVDQLYLIRKTLGDLIPRHQQVFSTNQYFSGVKIPDPE...............DMEPLELKFPNISYPALGLLKGCLHMDPTERLT.....CEQLLHHPYF MAK_RAT/4-284 YTTMRQLGDGTYGSV..LMGKSNESGE........LVAIKRMKRKFYSWDECMNLR....................EVKSLKKL.N...HANV..IKLKEVIRE..................NDHLY..FIFEYMKENLYQLMKDR.......................NKLF...PESVIRNIMYQILQGLAFIHK.H..........GFFHRDMKPENLLCM.GPELV...................KIADFGLARE..................LRSQP.PYTDYVSTRWYRAP....EV....LL..............RSSVYSSPIDVWAVGSIMAELYT.....FR......PLFP.GT.....SEVDEIFKICQVLGTPKKSDWPEGYQLASSMNFRFPQCI................PINLKTLIPNASSEAIQLMTEMLNWDPKKRPT.....ASQALKHPYF SGV1_YEAST/60-366 YREDEKLGQGTFGEV..YKGIHLETQR........QVAMKKIIVSVEKDLFPITAQR...................EITILKRL.N...HKNI..IKLIEMVYDHSPDIT.....NAASSNLHKSFY..MILPYMVADLSGVLHNP.......................RINL...EMCDIKNMMLQILEGLNYIHC.A..........KFMHRDIKTANILID.HNGVL...................KLADFGLARLYYGCPPN.....LKYPGGAGSGA.KYTSVVVTRWYRAP....EL....VL..............GDKQYTTAVDIWGVGCVFAEFFE.....KK......PILQ.GK.....TDIDQGHVIFKLLGTPTEEDWAVARYLPGAELTTTNYK.................PTLRERFGKYLSETGLDFLGQLLALDPYKRLT.....AMSAKHHPWF KI28_YEAST/7-290 YTKEKKVGEGTYAVV..YLGCQHSTGR........KIAIKEIKTSEFKDGLDMSAIR...................EVKYLQEM.Q...HPNV..IELIDIFMA..................YDNLN..LVLEFLPTDLEVVIKDK.......................SILF...TPADIKAWMLMTLRGVYHCHR.N..........FILHRDLKPNNLLFS.PDGQI...................KVADFGLARAI.................PAPHE.ILTSNVVTRWYRAP....EL....LF..............GAKHYTSAIDIWSVGVIFAELML.....RI......PYLP.GQ.....NDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPP...............SRDELRKRFIAASEYALDFMCGMLTMNPQKRWT.....AVQCLESDYF CC21_MEDSA/1-284 GENVEKIGEGTYGVV..YKARDRVTNE........TIALKKIRLEQEDEGVPSTAIR...................EISLLKEM.Q...HRNI..VRLQDVVHS..................DKRLY..LVFEYLDLDLKKHMDSS.PEFIK........................DPRQVKMFLYQMLCGIAYCHS.H..........RVLHRDLKPQNLLIDRRTNSL...................KLADFGLARAF.................GIPVR.TFTHEVVTLWYRAP....EI....LL..............GSRHYSTPVDVWSVGCIFAEMAN.....RR......PLSP.GD.....SEIDELFKIFRILGTPNEDTWPGVTSLPDFKSTFPRWP.................SKDLATVVPNLEPAGLDLLNSMLCLDPTKRIT.....ARSAVEHEYF CTK1_YEAST/183-469 YLRIMQVGEGTYGKV..YKAKNTNTEK........LVALKKLRLQGEREGFPITSIR...................EIKLLQSF.D...HPNV..STIKEIMVE.................SQKTVY..MIFEYADNDLSGLLLNK.......................EVQI...SHSQCKHLFKQLLLGMEYLHD.N..........KILHRDVKGSNILID.NQGNL...................KITDFGLARK..................MNSRA.DYTNRVITLWYRPP....EL....LL..............GTTNYGTEVDMWGCGCLLVELFN.....KT......AIFQ.GS.....NELEQIESIFKIMGTPTINSWPTLYDMPWFFMIMPQQTTKY............VNNFSEKFKSVLPSSKCLQLAINLLCYDQTKRFS.....ATEALQSDYF KG3A_RAT/119-403 YTDIKVIGNGSFGVV..YQARLAETRE........LVAIKKVLQDKRFKNR.........................ELQIMRKL.D...HCNI..VRLRYFFYSSG..............EKKDELYLNLVLEYVPETVYRVARHF....................TKAKLII...PIIYVKVYMYQLFRSLAYIHS.Q..........GVCHRDIKPQNLLVD.PDTAV..................LKLCDFGSAKQ..................LVRGE.PNVSYICSRYYRAP....EL....IF..............GATDYTSSIDVWSAGCVLAELLL.....GQ......PIFP.GD.....SGVDQLVEIIKVLGTPTREQIREMNPNYTEFKFPQIKA.................HPWTKVFKSRTPPEAIALCSSLLEYTPSSRLS.....PLEACAHSFF KPRO_MAIZE/534-812 RKFKVELGRGESGTV..YKGVLEDDRH.........VAVKKLENVRQGKEVFQA......................ELSVIGRI.N...HMNL..VRIWGFCSE..................GSHRL..LVSEYVENG.....SLA..NILF................SEGGNILLDWEGRFNIALGVAKGLAYLHH.EC.......LEWVIHCDVKPENILLD.QAFEP...................KITDFGLVKLLN...............RGGSTQ.NVSHVRGTLGYIAP....EW....VS...............SLPITAKVDVYSYGVVLLELLT.....G.......TRVS.ELVGGTDEVHSMLRKLVRMLSAKLEGEEQSWIDGYLDSKLN.........................RPVNYVQARTLIKLAVSCLEEDRSKRPT.....MEHAVQT..L PHY1_CERPU/1004-1282 IQITGSLGSGSSATV..EKAVWLGTP..........VAKKTFYGRNNEDFKR........................EVEILAEL.C...HPNI..TSMFCSPLY..................RRKCS..IIMELMDG......DLL..ALMQ.......RRLDRNEDHDSPPF...SILEVVDIILQTSEGMNYLHE.K..........GIIHRDLKSMNILVK.SVKVTKSEI..........GYVHVKVADFGLSKTKD...............SSTRYS.NQTWNRGTNRWMAP....EV....INLGYESTEGEISFDGKVPKYPLKSDVYSFGMVCYEVLT.....GD......VPFPEEK.....NPNNVKRMVLEGVRPDLPAHCP.............................................IELKALITDCWNQDPLKRPS.....FAVICQK..L M3K9_HUMAN/3-262 LTLEEIIGIGGFGKV..YRAFWIGDE..........VAVKAARHDPDEDISQTIENVR.................QEAKLFAML.K...HPNI..IALRGVCLK..................EPNLC..LVMEFARGG.....PLN..RVLS.................GKRI...PPDILVNWAVQIARGMNYLHDEAI........VPIIHRDLKSSNILIL.QKVENGDLS...........NKILKITDFGLAR...................EWHRT.TKMSAAGTYAWMAP....EV....IR...............ASMFSKGSDVWSYGVLLWELLT.....GE......VPFR.GI....DGLRVAYGVAMNKLALPIPSTCP.............................................EPFAKLMEDCWNPDPHSRPS.....FTNILDQ..L MIL_AVIMH/82-339 VLLSTRIGSGSFGTV..YKGKWHGD...........VAVKILKVVDPTPEQFQAFRN...................EVAVLRKT.R...HVNI..LLFMGYMT...................KDNLA..IVTQWCEGS.....SLY..KHLH...............VQETKF...QMFQLIDIARQTAQGMDYLHA.K..........NIIHRDMKSNNIFLH.GGLTV...................KIGDFGLATVKS...............RWSGSQ.QVEQPTGSILWMAP....EV....IRM............QDSNPFSFQSDVYSYGIVLYELMT.....GE......LPYS.HI.....NNRDQIIFMVGRGYASPDLSKLYKNCP........................................KAMKRLVADCLKKVREERPL.....FPQILSS..I AVR1_HUMAN/208-495 ITLLECVGKGRYGEV..WRGSWQGEN..........VAVKIFSSRDEKSWFRET......................ELYNTVML.R...HENI..LGFIASDMTSR..............HSSTQLW..LITHYHEMG.....SLY..DYLQ.................LTTL...DTVSCLRIVLSIASGLAHLHI.EIFGT..QGKPAIAHRDLKSKNILVK.KNGQC...................CIADLGLAVMHSQ.............STNQLDV.GNNPRVGTKRYMAP....EVLDETIQ.............VDCFDSYKRVDIWAFGLVLWEVARR.MVSNGIVEDYKPPFY.DVVPNDPSFEDMRKVVCVDQQRPNIPNRWFSDPTL.......................................TSLAKLMKECWYQNPSARLT.....ALRIKKT..L AVR2_HUMAN/192-479 LQLLEVKARGRFGCV..WKAQLLNEY..........VAVKIFPIQDKQSWQNEY......................EVYSLPGM.K...HENI..LQFIGAEKRGT..............SVDVDLW..LITAFHEKG.....SLS..DFLK.................ANVV...SWNELCHIAETMARGLAYLHE.DIPGLKDGHKPAISHRDIKSKNVLLK.NNLTA...................CIADFGLALKFE...............AGKSAG.DTHGQVGTRRYMAP....EVLEGAIN..............FQRDAFLRIDMYAMGLVLWELASRCTAADGPVDEYMLPFE.EEIGQHPSLEDMQEVVVHKKKRPVLRDYWQKHAGM.......................................AMLCETIEECWDHDAEARLS.....AGCVGER..I CC15_YEAST/25-272 YHLKQVIGRGSYGVV..YKAINKHTDQ........VVAIKEVVYENDEELNDIMA.....................EISLLKNL.N...HNNI..VKYHGFIRK..................SYELY..ILLEYCANG.....SLR..RLIS...............RSSTGL...SENESKTYVTQTLLGLKYLHG.E..........GVIHRDIKAANILLS.ADNTV...................KLADFGVS....................TIVNS.SALTLAGTLNWMAP....EI....LG...............NRGASTLSDIWSLGATVVEMLT.....KN......PPYH.NL.....TDANIYYAVENDTYYPPSSFS..............................................EPLKDFLSKCFVKNMYKRPT.....ADQLLKHVWI BYR2_SCHPO/394-658 WIRGALIGSGSFGQV..YLGMNASSGE........LMAVKQVILDSVSESKDRHAKLLDA.............LAGEIALLQEL.S...HEHI..VQYLGSNLN..................SDHLN..IFLEYVPGG.....SVA..GLLT................MYGSF...EETLVKNFIKQTLKGLEYLHS.R..........GIVHRDIKGANILVD.NKGKI...................KISDFGISKKLELN...........STSTKTGG.ARPSFQGSSFWMAP....EV....VK...............QTMHTEKTDIWSLGCLVIEMLT.....SK......HPYP.NC.....DQMQAIFRIGENILPEFPSNIS.............................................SSAIDFLEKTFAIDCNLRPT.....ASELLSHPFV ST20_YEAST/620-871 YANLVKIGQGASGGV..YTAYEIGTNV........SVAIKQMNLEKQPKKELIIN.....................EILVMKGS.K...HPNI..VNFIDSYVL..................KGDLW..VIMEYMEGG.....SLT..DVVT.................HCIL...TEGQIGAVCRETLSGLEFLHS.K..........GVLHRDIKSDNILLS.MEGDI...................KLTDFGFCAQI.................NELNL.KRTTMVGTPYWMAP....EV....VS...............RKEYGPKVDIWSLGIMIIEMIE.....GE......PPYL.NE.....TPLRALYLIATNGTPKLKEPENLS...........................................SSLKKFLDWCLCVEPEDRAS.....ATELLHDEYI MKK1_YEAST/221-488 IETLGILGEGAGGSV..SKCKLKNGSK........IFALKVINTLNTDPEYQKQIFR...................ELQFNRSF.Q...SEYI..VRYYGMFTDD................ENSSIY..IAMEYMGGR.....SLD..............AIYKNLLERGGRI...SEKVLGKIAEAVLRGLSYLHE.K..........KVIHRDIKPQNILLN.ENGQV...................KLCDFGVSG...................EAVNS.LATTFTGTSFYMAP....ER....IQ...............GQPYSVTSDVWSLGLTILEVAN.....GK......FPCS.SE.....KMAANIAPFELLMWILTFTPELKDEPESNI..................................IWSPSFKSFIDYCLKKDSRERPS.....PRQMINHPWI STE7_YEAST/191-466 LVQLGKIGAGNSGTV..VKALHVPDSK........IVAKKTIPVEQNNSTIINQLVR...................ELSIVKNVKP...HENI..ITFYGAYYNQ...............HINNEII..ILMEYSDCG.....SLD..KILSVY...KRFVQRGTVSSKKTWF...NELTISKIAYGVLNGLDHLYRQY..........KIIHRDIKPSNVLIN.SKGQI...................KLCDFGVSK...................KLINS.IADTFVGTSTYMSP....ER....IQ...............GNVYSIKGDVWSLGLMIIELVT.....GE......FPLG.GHNDTPDGILDLLQRIVNEPSPRLPKDRIYS...........................................KEMTDFVNRCCIKNERERSS.....IHELLHHDLI BYR1_SCHPO/66-320 LEVVRHLGEGNGGAV..SLVKHRNI...........FMARKTVYVGSDSKLQKQILR...................ELGVLHHC.R...SPYI..VGFYGAFQY..................KNNIS..LCMEYMDCG.....SLD..AILR................EGGPI...PLDILGKIINSMVKGLIYLYNVL..........HIIHRDLKPSNVVVN.SRGEI...................KLCDFGVSG...................ELVNS.VAQTFVGTSTYMSP....ER....IR...............GGKYTVKSDIWSLGISIIELAT.....QE......LPWSFSNIDDSIGILDLLHCIVQEEPPRLPSSFP.............................................EDLRLFVDACLHKDPTLRAS.....PQQLCAMPYF KMOS_CERAE/60-338 VCLLQRLGAGGFGSV..YKATYHGVP..........VAIKQVNKCTKNRLASRRSFWA..................ELNVARLR.....HDNI..VRVVAASTRT...............PAGSNSLGTIIMEFGGNV.....TLH..QVIYGAASHPEGDAGEPHCSTGGPL...TLGKCLKYSLDVVNGLLFLHS.Q..........SIVHLDLKPANILIS.EQDVC...................KISDFGCSEKLE..............DLLCFQT.PLYPLGGTYTHRAP....EL....LK...............GEGVTPKADIYSFAITLWQMTT.....KQ......APYS.GE.....RQHILYAVVAYDLRPSLSAAVFQDSLPG.......................................QRLGDVIRRCWRPSAAQRPS.....ARPLLVD..L PKN1_MYXXA/59-320 FRLVRRLGRGGMGAV..YLGEHVSIGS........RVAVKVLHAHLTMYPELVQRFHA..................EARAVNLI.G...HENI..VSIFDMDAT..................PPRPY..LIMEFLDGA.....PLS....................AWVGTPL...AAGAVVSVLSQVCDALQAAHA.R..........GIVHRDLKPDNIFLV.RRNGNAP...............FVKVLDFGIAKLAD...............AHMPQT.HAGIIVGTPEYMAP....EQ....SL...............GRGVDGRADLYALGVIAYQLLT.....GR......LPFN.DE.....GLAAQLVAHQLRPPPPPSSVYPAVS..........................................AALEHVILRALAKKPEDRYA....SIAAFRNALQV KKL6_YEAST/192-508 WKKVRPIGSGNFSTVLLYELMDQSNPKL......KQVAVKRLKYPEELSNVEQINTSLRYKETLS...RLENSLTRELQVLKSL.N...HPCI..VKLLGIN.NPIFVTSKKPLCDLIIKTPRALPPCDMIMSYCPAG.....DLL..AAVM...............ARNGRL...EAWLIQRIFTEVVLAVKYLHE.N..........SIIHRDLKLENILLK...YSFDDINSFRDS.PIYCKQNFIELADFGLCKK..................IENNE.MCTARCGSEDYVSP....EI....LM..............GVPYDGHLSDTWALGVILYSLFE.....DR......LPFD.PP.....PNASARQRSRATSHRIARFDWRWYRLSDY....................................KTNVGKQIVENTLTRKNQRWS......INEIYESPFV NPR1_YEAST/438-742 IKTGADLGAGAGGSV..KLAQRISDNK........IFAVKEFRTKFENESKRDYVKKI................TSEYCIGTTL.N...HPNI..IETIEIVYE..................NDRIL..QVMEYCEY......DLF..AIVM.................SNKM...SYEEICCCFKQILTGVQYLHS.I..........GLAHRDLKLDNCVIN.EKGIV...................KLIDFGAAVVFSY.............PFSKNLV.EASGIVGSDPYLAP....EV....CI..............FAKYDPRPVDIWSSAIIFACMIL.....KK......FPWKIPK.....LRDNSFKLFCSGRDCDSLSSLVTRTPDPPSYDESHSTEKKKPESSSNNVSDPNNVNIGPQRLLHSLPEETQHIVGRMIDLAPACRGN.....IEEIMEDPWI SAT4_YEAST/316-590 GRCQEVLGKGAFGVV..RICQKKNVSSQDGNKSEKLYAVKEFKRRTSESAEKYSKRLT.................SEFCISSSL.H...HTNI..VTTLDLFQD.................AKGEYC..EVMEYCAGG.....DLF..TLVV................AAGKL...EYMEADCFFKQLIRGVVYMHE.M..........GVCHRDLKPENLLLT.HDGVL...................KITDFGNSECFKM.............AWEKNIH.LSGGVCGSSPYIAP....EE....YI..............KEEFDPRPVDIWACGVIYMAMRT.....GR......QLWS.SA.....EKDDPFYMNYLKGRKEKGGYEPIESLKR.......................................ARCRNVIYSMLDPVPYRRIN.....GKQILNSEWG RAN1_SCHPO/18-295 LRFVSIIGAGAYGVV..YKAEDIYDGT........LYAVKALCKDGLNEKQKKLQAR...................ELALHARVSS...HPYI..ITLHRVLET..................EDAIY..VVLQYCPNG.....DLF..TYIT.................EKKVYQGNSHLIKTVFLQLISAVEHCHS.V..........GIYHRDLKPENIMVG.NDVNT..................VYLADFGLA....................TTEPY.SSDFGCGSLFYMSPECQREVKKLSSLSDMLPVTPEPIESQSSSFATAPNDVWALGIILINLCC.....KR......NPWK.RACSQTDGTYRSYVHNPSTLLSILPIS...............................................RELNSLLNRIFDRNPKTRIT.....LPELSTL..V KR1_PRVKA/53-332 FEVLQPLQSGSEGRV..FVARRPGEAD........TVVLKVGQKPSTLM...........................EGMLLQRL.S...HDNV..MRMKQMLAR..................GPATC..LVLPHFRC......DLY..SYLT...............MRDGPL...DMRDAGCVIRAVLRGLAYLHG.M..........RIMHRDVKAENIFLE.DVDTV...................CLGDLGAARC..................NVAAP.NFYGLAGTIETNAP....EV....LA...............RDRYDTKVDVWGAGVVLFETLA.............YPKT.ITGGDEPAINGEMHLIDLIRALGVHPEEFPPDTRLRSEFVRYAGTHRQ............PYTQYARVARLGLPETGAFLIYKMLTFDPVRRPS.....ADEILNFGMW KR1_HHV11/191-478 FTIHGALTPGSEGCV..FDSSHPDYPQ........RVIVKAGWYTSTSH...........................EARLLRRL.D...HPAI..LPLLDLHVV..................SGVTC..LVLPKYQA......DLY..TYLS...............RRLNPL...GRPQIAAVSRQLLSAVDYIHR.Q..........GIIHRDIKTENIFIN.TPEDI...................CLGDFGAACFVQ...............GSRSSP.FPYGIAGTIDTNAP....EV....LA...............GDPYTTTVDIWSAGLVIFETAV.....HN......ASLF.SAPRGPKRGPCDSQITRIIRQAQVHVDEFSPHPESRLTSRYRSRAAGNN.........RPPYTRPAWTRYYKMDIDVEYLVCKALTFDGALRPS.....AAELLCLPLF WEE1_HUMAN/299-569 FHELEKIGSGEFGSV..FKCVKRLDGC........IYAIKRSKKPLAGSVDEQNALR...................EVYAHAVLGQ...HSHV..VRYFSAWAE..................DDHML..IQNEYCNGG.....SLA..DAIS...............ENYRIMSYFKEAELKDLLLQVGRGLRYIHS.M..........SLVHMDIKPSNIFIS.RTSIPNAASEEGDEDDWASNKVMFKIGDLGH.....................VTRIS.SPQVEEGDSRFLAN....EV....LQ..............ENYTHLPKADIFALALTVVCAAG.....AE......PLPR.NGDQWHEIRQGRLPRIPQVLS.....................................................QEFTELLKVMIHPDPERRPS.....AMALVKHSVL HR25_YEAST/9-273 FRIGRKIGSGSFGDI..YHGTNLISGE........EVAIKLESIRSRHPQLDY.......................ESRVYRYL.S...GGVG..IPFIRWFGR.................EGEYNA..MVIDLLGPSLEDLFNYC.......................HRRF...SFKTVIMLALQMFCRIQYIHG.R..........SFIHRDIKPDNFLMG..VGRRGS...............TVHVIDFGLSKKYRDF..........NTHRHIPYR.ENKSLTGTARYASV....NT....HL...............GIEQSRRDDLESLGYVLIYFCK.....GS......LPWQ.GL.....KATTKKQKYDRIMEKKLNVSVETLCSGL......................................PLEFQEYMAYCKNLKFDEKPD.......YLFLARLF